When the food stopped coming Even, the genes continued to activate at the expected mealtime. This may be an entrance to the whole mystical arena of how metabolic circumstances in an pet can synchronize themselves with a body time clock, said Dr. Masashi Yanagisawa, professor of molecular genetics and senior author of the study. The UT Southwestern experts report their findings in the Aug. 8 issue of the Proceedings of the National Academy of Sciences. The daily ups-and-downs of waking, eating and various other bodily processes are known as circadian rhythms, which are regulated by many external and internal forces.Like human beings with type 1 diabetes, dogs develop diabetes after a dramatic lack of beta cells. Without a significant number of beta cells, the pancreas struggles to produce enough insulin. That insulin should be replaced through injections. But the experts found some key differences if they dug deeper. ‘There were some real surprises,’ said Kushner. ‘Canines had hardly any islets. In man and mouse, there are often residual islets, but these canines had hardly any left. It suggests some kind of really aggressive procedure destroying those cells.’ However, the researchers didn’t find evidence of irritation or an autoimmune assault in the islet cells, as happens with humans. Kushner said it is possible they were looking too late in the course of the disease to start to see the autoimmune strike, and that remains an open study question.